Table 1.
Participant demographics. pH data available for 94 individuals; contraception data available for 62 individuals; gravidity and parity data available for 93 individuals; previous loop electrosurgical excision procedure (LEEP) data available for 86 individuals.
| n | Ctrl HPV−(n = 20) | Ctrl HPV+ (n = 31) | LGD (n = 12) | HGD (n = 27) | Cancer (n = 10) | P value | |
|---|---|---|---|---|---|---|---|
| Age (mean (SD)) | 100 | 39.55 (7.35) | 37.64 (9.38) | 35.08 (7.24) | 38.29 (8.46) | 38.90 (9.09) | 0.64 |
| Ethnicity (n (%)) | |||||||
| Hispanic | 47 | 5 (25.00) | 14 (45.16) | 7 (58.33) | 17 (62.96) | 4 (40.00) | |
| Non-Hispanic | 53 | 15 (75.00) | 17 (54.84) | 5 (41.67) | 10 (37.04) | 6 (60.00) | 0.11 |
| pH (n (%)) | |||||||
| ≤4.5 | 20 | 9 (45.00) | 6 (22.22) | 3 (27.27) | 2 (7.41) | 0 (0.00) | |
| >4.5 | 74 | 11 (55.00) | 21 (77.78) | 8 (72.73) | 25 (92.59) | 9 (100.00) | 0.01 |
| BMI (n (%)) | |||||||
| ≤25 | 34 | 7 (35.00) | 12 (38.71) | 4 33.33) | 8 (29.63) | 3 (30.00) | |
| >25 | 66 | 13 (65.00) | 19 (61.29) | 8 (66.67) | 19 (70.37) | 7 (70.00) | 0.96 |
| Type of contraception | |||||||
| Hormonal: yes | 22 | 2 (18.18) | 11 (52.38) | 3 (42.86) | 2 (11.11) | 4 (80.00) | 0.02 |
| Hormonal: no | 27 | 4 (36.36) | 8 (38.10) | 2 (28.57) | 12 (66.67) | 1 (20.00) | |
| No contraception | 13 | 5 (45.45) | 2 (9.52) | 2 (28.57) | 4 (22.22) | 0 (0.00) | |
| HPV status | |||||||
| HPV16 positive | 17 (54.84) | 8 (72.73) | 19 (70.37) | 7 (70.00) | 0.59 | ||
| HPV18 positive | 0 (0.00) | 1 (9.09) | 4 (14.81) | 1 (10.00) | 0.11 | ||
| Other high-risk | 18 (58.06) | 10 (83.33) | 19 (70.37) | 4 (40.00) | 0.16 | ||
| Low-risk | 5 (16.13) | 0 (0.00) | 1 (3.70) | 1 (10.00) | 0.26 | ||
| HPV risk profile | |||||||
| Single high-risk | 14 (45.16) | 3 (25.00) | 13 (48.15) | 7 (70.00) | 0.23 | ||
| Multiple high-risk | 12 (38.71) | 8 (66,67) | 13 (48.15) | 2 (20.00) | 0.16 | ||
| High- and low-risk | 26 (83.87) | 11 (91.67) | 26 (96.30) | 9 (90.00) | 0.46 | ||
| Gravidity (n (%)) | |||||||
| 0 | 15 | 3(15.00) | 6 (21.43) | 1 (8.33) | 1 (4.17) | 4 (44.44) | 0.25 |
| 1–4 | 58 | 14 (70.00) | 15 (53.57) | 8 (66.67) | 18 (75.00) | 3 (33.33) | |
| 5+ | 20 | 3 (15.00) | 7 (25.00) | 3 (25.00) | 5 (20.83) | 2 (22.23) | |
| Parity (n (%)) | |||||||
| 0 | 20 | 4 (20.00) | 8 (28.57) | 1 (8.33) | 3 (12.50) | 4 (44.44) | 0.51 |
| 1–4 | 61 | 14 (70.00) | 17 (60.71) | 8 (66.67) | 18 (75.00) | 4 (44.44) | |
| 5+ | 12 | 2 (10.00) | 3 (10.72) | 3 (25.00) | 3 (12.50) | 1 (11.12) | |
| Previous LEEP (n (%)) | |||||||
| No | 68 | 13 (81.25) | 19 (70.37) | 10 (100.00) | 20 (83.33) | 6 (66.67) | 0.27 |
| Yes | 18 | 3 (18.75) | 8 (29.63) | 0 (0.00) | 4 (16.67) | 3 (33.33) | |
P values calculated using ANOVA for continuous variables and Fisher’s exact test for categorical variables.