Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 May 15;9:1910. doi: 10.1038/s41467-018-04295-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — Changes in interaction of pfap2 genes and invasion genes with the repressive center. a Colocalization of pfap2-g and var gene PF3D7_0800300 by DNA-FISH. Additional images are presented in Supplementary Fig. 8. b Dissociation of the gametocyte-specific transcription factor locus pfap2-g (red) from the nearby internal virulence gene cluster (yellow) in stage II/III gametocytes. c Overall reduced number of intrachromosomal and interchromosomal interactions between pfap2 TF genes and virulence genes in gametocytes and sporozoites as compared to the IDC stages. d Invasion gene clusters (blue bar) on chromosomes 2 (top) and 10 (bottom) interact with subtelomeric virulence genes (yellow bar) in gametocytes, but not during the IDC. In each plot, the top triangle shows the aggregated data of both gametocyte stages, while the bottom triangle shows the aggregated data from the three IDC stages. Bins that depict interactions between virulence genes and invasion genes are highlighted by a red box. e Increased number of intrachromosomal and interchromosomal interactions between invasion genes and virulence genes in gametocytes and sporozoites as compared to the IDC stages