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. 2018 May 15;9:1910. doi: 10.1038/s41467-018-04295-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Changes in genome organization in salivary gland sporozoites. a Locations of rDNA genes in the P. falciparum genome. Units of 28S, 5.8S, and 18S genes on chromosomes 1, 5, 7, 11, and 13 are indicated with a filled symbol. Several additional rDNA genes are located on other chromosomes, including a unit of three 5S genes on chromosome 14, which is indicated with an open symbol. b Increased overall number of interactions between rDNA genes and virulence genes in P. falciparum sporozoites. c Loss of domain formation around the rDNA locus on chr7 in P. falciparum sporozoites as compared to other life cycle stages. The borders of the rDNA locus are indicated by red lines. d Strong interchromosomal interactions in P. vivax sporozoites, indicated by white rectangles. Dashed lines indicate chromosome boundaries