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. 2018 May 15;8:7573. doi: 10.1038/s41598-018-25845-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Enrichment analysis of KEGG pathways in comparisons of different stages. The x-axis indicates the p value calculated in enrichment test. Numbers of genes that were up-regulated (red) or down-regulated (blue) in comparisons of (a) EggI vs. Second instar and Second vs. third instar, (b) Third vs. adult and Adult female vs. EggI are shown. The size of circles indicates the number of genes in that pathway. Red circles represented up-regulated genes, while blue circles represented down-regulated genes.