Table 3.
Clinical factors as they independently relate to FA, RD, and AD values of each corpus callosum subregion.
| CC Subregion |
Mean FA Difference (95% CI) | Mean RD Difference (95% CI) | Mean AD Difference (95% CI) |
|---|---|---|---|
| Splenium | PMA 0.00472 (0.00371, 0.00569)*** MA −0.00172 (−0.00313, −0.000318)* BW 0.00609 (0.00303, 0.00918)* |
PMA −0.0121 (−0.0162, −0.00810)*** BW −0.023 (−0.0393, −0.00673)* Apgar 0.167 (0.0654, 0.268)* |
Apgar 0.142 (0.0491, 0.235)* |
| Isthmus | PMA 0.00237 (0.00176, 0.00298)*** BW 0.00470 (0.00182, 0.0076)* |
PMA −0.01057 (−0.0156, −0.0055)** | |
| PMB | PMA 0.002149 (0.00135, 0.00295)*** BW 0.00374 (0.000937, 0.0065)* |
PMA −0.00672 (−0.0109, −0.00253)* Male 0.182 (0.0449, 0.319)* |
Male 0.188 (0.0219, 0.354)* |
| AMB | PMA 0.00183 (0.000914, 0.00274)* BW 0.00333 (0.0059, 0.0308)* |
PMA 0.02608 (0.00827, 0.0439)* PMA2 −0.00122 (−0.00191, −0.00053)* DCT 0.00339 (0.000954, 0.0058)* EDU 0.1353 (0.0258, 0.2448)* Apgar 0.2275 (0.1249, 0.33)** Male 0.1387 (0.0268, 0.2506* |
PMA 0.0378 (0.0149, 0.0607)* PMA2 −0.00142 (−0.00231, −0.00053)* DCT 0.00335 (0.000197, 0.0065)* EDU 0.180 (0.0505, 0.310)* Apgar 0.165 (0.0669)* |
| RB | PMA 0.00157 (0.000611, 0.00254)* BW 0.00342 (0.0011, 0.00575)* |
PMA 0.0308 (0.0154, 0.0462)** PMA2 −0.00138 (−0.00198, −0.00078)***EDU 0.1343 (0.0159, 0.253)* No BPD −0.2227 (−0.364, −0.0812)* Apgar 0.167 (0.0493, 0.285)* |
PMA 0.04211 (0.0341, 0.296)*** PMA2 −0.00155 (−0.00230, −0.00080)** EDU 0.1547 (0.0158, 0.294)* No BPD −0.228 (−0.395, −0.0608)* |
| Genu | PMA 0.004377 (0.00355, 0.0052)*** BW 0.00350 (0.000638, 0.00636)* |
PMA −0.02072 (−0.0251, −0.0163)*** BW −0.015 (−0.0287, −0.00128)* |
PMA 0.02403 (0.00398, 0.0441)* PMA2 −0.00119 (−0.00189, −0.00049)* |
*P < 0.05, **P < 0.01, ***P < 0.001
Note: All RD and AD values should be multiplied by 10−3. Coefficient for BW represents a difference in birth weight of 100 grams. Abbreviations: CC: corpus callosum; CI: confidence interval; PMB: posterior midbody of CC; AMB: anterior midbody of CC; RB: rostral body of CC; PMA: postmenstrual age at MRI scan; PMA2 quadratic term of PMA; BW: birth weight; MA: maternal age; Apgar: score ≤5 at 5 minutes after birth; DCT: total number of days on caffeine therapy; EDU: maternal education level (below college level); BPD: bronchopulmonary dysplasia.