TABLE 1.
GO categories of all mH2A1.2 target genes (within 5 kb on either side of the TSS)a in hESCs and human fibroblasts
| Biological function(s) (GO category) | Log10
P valueb |
|
|---|---|---|
| hESCs | hFBSs | |
| Phosphoprotein | 26.40 | |
| Nucleus | 14.27 | |
| Chromosome, chromosome organization | 13.36 | |
| Chromatin, chromatin assembly or disassembly, chromatin remodeling by hSWI/SNF ATP-dependent complexes | 8.80 | |
| Cell cycle, positive regulation of cell cycle | 8.00 | 1.06 |
| DNA metabolic process | 6.37 | 4.27 |
| Microtubule cytoskeleton, intermediate filament | 5.85 | 1.02 |
| Cell division, regulation of cell division, cell proliferation | 5.85 | |
| Histone core | 5.10 | |
| Protein transport, establishment of protein localization | 5.01 | |
| Protein biosynthesis, negative regulation of macromolecule biosynthetic process, regulation of cellular protein | 4.96 | |
| Nucleosome, histone H2A, histone H2B | 4.77 | |
| Methylation | 4.70 | |
| Translation | 4.44 | |
| Cellular response to stress | 4.43 | |
| Alternative splicing, RNA processing | 4.40 | 3.80 |
| DNA damage, DNA repair | 4.35 | |
| Repressor, negative regulation of transcription | 3.89 | |
| Transcription factor binding, transcription cofactor activity | 3.85 | |
| Ribosome | 3.32 | |
| Transcription, regulation of transcription | 2.29 | 1.10 |
| mRNA transport, posttranscriptional regulation of gene expression | 2.19 | |
| Negative regulation of cell development | 1.62 | |
| Regulation of DNA replication | 1.52 | |
| Ribosome biogenesis, ribosome binding | 1.49 | |
| Positive regulation of specific transcription from RNA polymerase II promoter | 1.44 | |
| Hemopoietic stem cell differentiation | 1.40 | |
| In utero embryonic development, developmental protein, development | 1.33 | 1.82 |
| Positive regulation of cell development, positive regulation of multicellular organism growth, developmental growth | 1.19 | |
| Neuron development, regulation of neurogenesis, regulation of nervous system development, neuron differentiation | 1.05 | 1.68 |
| Glycoprotein | 19.30 | |
| Signal, cell-cell signaling | 12.08 | |
| Secreted | 10.23 | |
| Receptor | 7.24 | |
| Keratin | 4.17 | |
| G-protein-coupled receptor protein signaling pathway | 4.07 | |
| Immune response, defense response | 3.22 | |
| Pattern binding, axonogenesis | 2.89 | |
| Epithelial cell differentiation | 1.66 | |
| Skeletal system development | 1.59 | |
| Extracellular matrix, collagen | 1.54 | |
| Diencephalon development | 1.44 | |
| Positive regulation of biosynthetic process | 1.42 | |
| Cell morphogenesis involved in differentiation | 1.39 | |
| Cell adhesion, cell surface | 1.36 | |
| Fibroblast growth factor receptor binding | 1.29 | |
| Mesenchyme development | 1.23 | |
a
All genes occupied by mH2A1.2.
b
The P values indicate the statistical significance of the GO category in the two distinct cell types.