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Experimental setup. (A) Chromosomal resistance mutations were used to construct sets of single, double, triple, and quadruple combinatorial mutants in S. Typhimurium LT2, and the effects on growth and resistance were examined. (B) A set of 13 mutations were individually introduced into 10 different genetic backgrounds (generating 130 strains) to study how the genetic background of the strain affects the phenotypic expression of the resistance mutations.
