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. 2018 May 15;9(3):e00819-18. doi: 10.1128/mBio.00819-18

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Copyright © 2018 Szaniawski et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 2 — Macrophages exhibit diverse pSAMHD1-T592 signatures at baseline that correlate with infectivity. (A) Lysates of MDM from six donors were analyzed by Western blotting for pSAMHD1-T592, total SAMHD1, and actin. Numbers indicate the proportion of pSAMHD1-T592 to total SAMHD1 as calculated by Western blotting densitometry. Lanes were cut following development of a single membrane to remove alternating lanes. (B) Correlation between pSAMHD1-T592 and the percentage of GFP-positive macrophages as analyzed by flow cytometry. (C) Correlation between total SAMHD1 and the percentage of GFP-positive MDM. Linear regression analyses were performed to study the relationships between infectivity, total SAMHD1 levels, and pSAMHD1 levels.