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. 2018 May 15;9(3):e00819-18. doi: 10.1128/mBio.00819-18

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Copyright © 2018 Szaniawski et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 5 — siRNA to CDK1 and SAMHD1 reveal central roles in IFN-induced HIV-1 restriction. (A) The effect of CDK1/2 inhibition on infection with HIV-1ΔEnv-GFP/VSVG was determined by flow cytometry, with infection in untreated cells set at 100%. Data on cells from three representative donors are shown. (B) Western blot analysis of siRNA-treated MDM from donor A069. (C) Representative siRNA flow cytometry plots from two donors, donors A069 and A070. (D) Representative flow cytometry plots from IFN-treated MDM with and without SAMHD1 knockdown.