Table 3.

Evaluation of Test Characteristics at the Mean Outcome for a Sensitivity Near 95%

Test Result	True Positive	True Negative	Total
Positive	80.5	3936.3	4016.8
Negative	4.3	5978.9	5983.2
Total	84.8	9915.2	10 000.0

Test estimates for the mean performance at both points were calculated using the assumption of prevalencein a high-risk screening cohort (Escobar et al [4]) of 1 in 118 (0.85%). Shown are hypothetical test characteristics in 10 000 tested neonates. Sensitivity = 94.9%, specificity = 60.3%, negative likelihood ratio = 0.085, positive likelihood ratio = 2.39, prevalence = 0.848%, negative predictive value = 99.93%, and positive predictive value = 2.0%.