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. 2018 May 9;9:1053. doi: 10.3389/fimmu.2018.01053

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Copyright © 2018 Sivakumar, Abboud, Mathews, Atkinson and Morel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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B6.Sle2c2 mice express lower levels of G-CSF-R on polymorphonuclear neutrophils (PMNs) and dendritic cells (DCs). (A) Representative histogram overlays showing G-CSF-R expression on splenic PMNs, macrophages (Mϕ), conventional DCs (cDCs), and CD4⁺, CD8α⁺, and DN DC subsets from B6 (plain) and B6.Sle2c2 (dashed) mice at steady state with the control shown in gray. (B) G-CSF-R expression (delta geometric mean) on myeloid cell subsets. Percentage of G-CSFRhi cells among PMNs (C), CD4⁺, CD8α⁺, and DN DCs (D), as well as CD4⁺ T cells (E) from B6 (open square) and B6.Sle2c2 (black-squares) mice at days 0 and 21 after chronic graft-versus-host disease (cGVHD) induction. (F) Representative FACS dot plots showing G-CSF-Rhi population within splenic PMNs, DN DCs and CD4⁺ T cells at day 21 post-cGVHD induction (N > 3 per subset and strain, **p < 0.01, ***p < 0.001).