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. 2018 May 9;9:1053. doi: 10.3389/fimmu.2018.01053

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Copyright © 2018 Sivakumar, Abboud, Mathews, Atkinson and Morel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Polymorphonuclear neutrophil (PMN) depletion partially rescued chronic graft-versus-host disease (cGVHD) in B6.Sle2c2 mice. (A) Spleen weight and splenocyte numbers 3 weeks after cGVHD induction in B6 and B6.Sle2c2 mice with and without PMN depletion with the 1A8 antibody. The graph of the right show relative between mice treated with 1A8 and controls for each strain. (B) Frequency and numbers of conventional DCs (cDCs) and Mϕ at week 3. Fold changes were calculated as [(depleted − controls)/controls] values. *p < 0.05 indicates significant differences versus the B6 value. Serum anti-dsDNA IgG fold changes at week 1 (C) and time course analysis (D) in the four groups (N = 3 per treatment per strain) ***p < 0.001 two-way ANOVA between strains either treated or untreated with 1A8.