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. 2018 May 9;9:1053. doi: 10.3389/fimmu.2018.01053

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Copyright © 2018 Sivakumar, Abboud, Mathews, Atkinson and Morel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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B6.Sle2c2 bone marrow-derived DCs (BMDCs) display a less inflammatory gene expression signature than B6 BMDCs. (A) Differential gene expression of B6 and B6.Sle2c2 BMDCs stimulated with 1 µg/ml LPS for 24 h (N = 3). CD40 (B), CD80 (C), and MHC-II (D) protein expression on unstimulated and LPS-stimulated BMDCs and the three splenic dendritic cell (DC) subsets from B6 and B6.Sle2c2 mice before and after chronic graft-versus-host disease induction. (E) CD154 expression on OT-II cells cocultured with BMDCs with or without OVA peptide for 72 h. (F) Cytokine levels in the supernatants of the cocultures, assessed by multi-analyte ELISA. The two graphs on the right show the relative ratios of IL-2 to IFNγ and IL-13 (N = 3–8, *p < 0.05; **p < 0.01).