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. 2018 May 9;9:1053. doi: 10.3389/fimmu.2018.01053

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Copyright © 2018 Sivakumar, Abboud, Mathews, Atkinson and Morel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Reduction of CD8α⁺ dendritic cells (DCs) by Batf3-deficiency enhances bm12.cGVHD autoimmune phenotypes. Phenotypes were analyzed 21 days after chronic graft-versus-host disease (cGVHD) induction with bm12 splenocytes in B6 and B6.Batf3^−/− mice. (A) Spleen weight, splenocyte numbers and serum anti-dsDNA IgG fold increase from day 0. (B) Frequencies of effector T cell (Teff), regulatory T cells (Treg), and Tfh cells and MFI of CD154 and ICOS on Teff cells. (C) Frequencies, absolute numbers, and ratios of the three DC subsets. (D) CD40, CD80, and MHC-II expression on splenic DC subsets (N = 6, *p < 0.05; **p < 0.01, ***p < 0.001, ****p < 0.0001).