Table 1.

Summary of mAb improvements in tested outcome measures.

Outcome measure		Syn-O1	Syn-O2	Syn-O4	Syn-F1	Syn-F2
Total α-syn levels improved vs. vehicle	Neocortex	✓		✓	✓
	Hippocampus	✓		✓
	Striatum	✓		✓	✓
	S. nigra	✓			✓	✓
PK-treated α-syn levels improved vs. vehicle	Neocortex	✓		✓
	Hippocampus	✓	✓	✓	✓	✓
	Striatum	✓	✓	✓
	S. nigra
α-Syn levels improved vs. vehicle (ELISA)	t-α-syn		✓
	h-α-syn			✓
	Oligo-α-syn	✓	✓	✓	✓	✓
	pS129-α-syn
	Aggregated α-syn	✓	✓	✓
Rescue neurodegeneration	NeuN	✓		✓	✓
Rescue neuroinflammation	GFAP	✓		✓
	Iba-1			✓
	Iba-1 ramification	✓		✓
Increase colocalization synapsin I and synaptophysin		✓		✓	✓
Reduce colocalization synaptophysin and α-syn		✓		✓	✓
Normalizing behavior	Total activity	✓		✓	✓
	Rearing
	Thigmotaxis