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. 2018 Apr 10;114(7):1657–1666. doi: 10.1016/j.bpj.2018.02.026

Figure 4.

Figure 4

Fall time analysis of force jump simulations (color online). (A) The average fall time calculated from force jump trajectories simulated using the same energy landscape as in Fig. 2A is shown for an isolated hairpin (black) and hairpin connected to bead via linker with stiffness k = 0.2 pN/nm (red). (B) The reciprocal of the exit flux for simulated trajectories is shown (black: isolated hairpin, red: 0.2 pN/nm linker stiffness). (C) The diffusivity profile calculated for the isolated hairpin (black) recovers the position-dependent diffusivity imposed in the simulation (cyan), but the profile calculated for the hairpin linked to a bead (red) does not recover the position-dependence and is instead close to constant. Error bars represent SE. To see this figure in color, go online.