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. 2018 Apr 10;114(7):1657–1666. doi: 10.1016/j.bpj.2018.02.026

Figure 5.

Figure 5

Kramers’s analysis of D for barriers at different positions (color online). The diffusion coefficient for barrier-crossing, determined from Kramers’s theory (Eq. 4) via landscape analysis of hairpins with barriers located at different positions, is the same within error for barrier positions spanning the range from close to the folded state to close to the unfolded state, which is consistent with a diffusivity that is roughly flat (dashed line). The open square shows hairpin 20TS06/T4, the open circle shows hairpin 20TS10/T4, the open diamond shows hairpin 20TS16/T4, the filled circle shows hairpin 20M07/T4 (two barriers), and the filled square shows hairpin 20M10/T4 (two barriers). Error bars represent SE. To see this figure in color, go online.