Table 1: Cardiovascular effects of sodium-glucose cotransporter 2 inhibitors based on clinical and mechanistic studies.

CV effect	Reference
Blood pressure ↓	26,27
Arterial stiffness ↓	30
Glucose and insulin ↓	26,28
Albuminuria ↓	27
Uric acid ↓	21,26
Weight ↓	29
Visceral adiposity ↓	29
Oxidative stress ↓	31
Triglycerides ↓	25,26
LDL-C ↑	24,25
HDL-C ↑	25,26,28

CV = cardiovascular; HDL-C = high density lipoprotein cholesterol; LDL-C = low density lipoprotein cholesterol; SNS = sympathetic nervous system