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EMD1214063 inhibits c-MET signaling in the Met-β-catenin hepatocellular carcinoma (HCC) mouse model. Western blot analysis using whole-liver lysates from control- and EMD1214063-treated groups at 8 and 11 weeks shows a notable decrease in the levels of p-Met (Tyr1234/1235), p-ERK1/2 (Thr202/Tyr204), p-AKT (Ser473), and p-STAT3 (Tyr705) levels in the EMD1214063-treated group. GAPDH shows comparable loading in all lanes.
