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EMD1214063 does not impact inflammation or fibrosis at 8 weeks or 11 weeks of treatment of Met-β-catenin mice. (A) IHC for CD45 shows comparable inflammatory cells both within and outside the tumor foci at 8 weeks or 11 weeks in controls or EMD1214063 treatment group. (B) Sirius Red staining shows lack of any hepatic fibrosis in control-treated Met-β-catenin mice at either 8 or 11 weeks. No differences between controls and EMD1214063 treatment were evident at either time points.
