Table 1.

Clinical characteristics of subjects

Classification	Age/Sex	Symptoms	Living arrangement	DRS	FDG-PET	PiB-PET	Tau-PET
Normal	54/F	None	Independent	143 (94%)	(−)	(−)	(−)
Clinically-Mild AD	78/M	Mild memory dysfunction. Rarely gets lost driving	Independent	120 (1%)	Precuneus hypometabolism	(+)	(+)
Clinically-Moderate AD	74/F	Memory poor. Gets lost. Reduced daily activity.	Assisted Living	96 (<1%)	Bilateral parietotemporal hypometabolism	(+)	(+)
Clinically-Severe AD (Severe-1)	84/M	Doesn’t recognize family. Needs help dressing and bathing. Incontinent.	Nursing home	83 (<1%)	Bilateral frontal, parietal, temporal hypometabolism	(+)	(+)
AD with radiologically severe hippocampal atrophy (Severe-2)	81/M	Severe memory loss. Gets lost driving and in home.	Independent	112 (<1%)	Bilateral parietotemporal, lateral occipital, precuneus, and posterior cingulate hypometabolism	(+)	(+)

Abbreviations: AD alzheimer’s disease, F female, M male, DRS dementia rating scale (144 point scale, lower scores indicate poorer cognitive functioning, age-related normal percentile indicated in parentheses [16]), FDG-PET [(18) F]-fluorodeoxyglucose positron emission tomography, PiB-PET Pittsburgh compound B positon emission tomography, Tau-PET tau positon emission tomography, (−) = negative scan results, (+) = positive scan results