Table 1.
Single-SNP associations with age at PD onset and risk of PD DRD2 (Taq 1A rs1800497), DRD3 (rs6280) and NMDA GRIN2B (rs7301328).
| Association with age at PD onset | ||||||||
|---|---|---|---|---|---|---|---|---|
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| SNP | MA | MAF | Additive model | Dominant model | Recessive model | |||
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| Regression coefficient (95% CI) | P-value | Regression coefficient (95% CI) | P-value | Regression coefficient (95% CI) | P-value | |||
| rs1800497 | A | 22.1% | 0.25 (−1.27, 1.78) | 0.75 | 0.07 (−1.78, 1.92) | 0.94 | 1.47 (−2.61, 5.56) | 0.48 |
| rs6280 | C | 32.7% | −1.59 (−2.96, −0.22) | 0.023 | −1.13 (−2.96, 0.70) | 0.22 | −4.42 (−7.38, −1.47) | 0.0034 |
| rs7301328 | C | 40.1% | 0.02 (−1.34, 1.38) | 0.98 | 0.94 (−0.98, 2.86) | 0.34 | −1.63 (−4.22, 0.95) | 0.22 |
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| Association with risk of PD | ||||||||
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| Additive model | Dominant model | Recessive model | ||||||
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| OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | |||
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| rs1800497 | A | 20.1% | 1.31 (1.08, 1.59) | 0.0065 | 1.36 (1.08, 1.71) | 0.0096 | 1.54 (0.89, 2.67) | 0.12 |
| rs6280 | C | 33.3% | 0.97 (0.82, 1.15) | 0.73 | 0.97 (0.77, 1.21) | 0.76 | 0.96 (0.68, 1.37) | 0.82 |
| rs7301328 | C | 39.1% | 1.11 (0.95, 1.31) | 0.20 | 1.26 (1.00, 1.59) | 0.048 | 0.97 (0.71, 1.33) | 0.86 |
SNP = single nucleotide polymorphism. MA = minor allele. MAF = minor allele frequency. OR = odds ratio. PD = Parkinson Disease. CI = confidence interval. MAFs in PD patients are given for associations with age at PD onset, while MAFs in the overall sample are given for associations with risk of PD. Single-SNP associations with age at PD onset were evaluated using linear regression models adjusted for gender. Regression coefficients and 95% CIs are interpreted as the increase in mean age at PD onset corresponding to each additional minor allele (additive models), presence of the minor allele (dominant models), or presence of two copies of the minor allele (recessive models). Single-SNP associations with risk of PD were evaluated using logistic regression models adjusted for age and gender. ORs correspond to each additional minor allele (additive models), presence of the minor allele (dominant models), or presence of two copies of the minor allele (recessive models). After applying a single-step minP permutation adjustment for multiple testing, P values ≤ 0.0073 (associations with age at PD onset) and ≤0.0077 (associations with risk of PD) were considered as statistically significant.