Scheme 5. Synthesis of the phosphoramidite of 8-Oxo-dG. Reagents and conditions: (a) DMF–DMA, MeOH, 50%; (b) (MeO)2TrCl, pyridine, 0 °C to rt, 12 h, 71%; (c) (i-Pr2N)2POC2H4CN, 1H-tetrazole, CH2Cl2, 0 °C to rt, 1 h, 81%.
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