Figure 4.

Effect of black garlic extract on liver histology from experimental mice. Liver sections from normal stained with HE revealed normal and steady architecture of hepatic parenchymal cells and portal space (a). There is no significant difference between liver sections from normal and SBE control mice stained with HE (b). CCl₄ intoxication led to severe hepatic inflammation with mononuclear cell infiltration surrounding hepatic veins accompanied by adjacent hepatocyte necrosis (c). Of note, treatment of SBE ameliorated inflammation response with mild mononuclear cell infiltration surrounding portal space with normal architecture of hepatocytes (d). The data demonstrated that black garlic extract attenuated hepatotoxicity and liver inflammation induced by CCl₄ administration. The scale bar is presented as 100 μm.