Table 2.
Qualitative analysis.
| Study author/year [reference] | Study type | n; age (years) | Variables | Case criteria (PD) | Saliva sample | Results 8-OHdG (ng/ml) |
Significant difference | NOS |
|---|---|---|---|---|---|---|---|---|
| Takane et al. 2002 [12] | CC | PD: 78; 21–69 C: 17; 24–64 |
8-OHdG | At least 2 sites with PP > 4 mm | S | PD 4.28 ± 0.10 C 1.56 ± 0.10 |
Yes | 8/10 |
| Sawamoto et al. 2005 [15] | CC | PD:29; 36–68 C: 20; 25–65 |
8-OHdG | At least 2 sites with PP > 4 mm | S | PD 4.36 ± 0.18 C: 1.48 ± 0.08 |
Yes | 8/10 |
| Takane et al. 2005 [13] | CC | PD: 18; 21–67 C: 17; 24–64 |
8-OHdG | At least 2 sites with PP > 4 mm | S | PD 2.35 ± 0.18 C 1.56 ± 0.1 |
Yes | 8/10 |
| Totan et al. 2006 [18] | CC | PD: 25; 25–55 C: 25; 25–55 |
AST ALT ALP |
PP > 5 mm, LA > 40% | NS | — | — | 8/10 |
| Greabu et al. 2006 [9] | CC | PD:30; 16–82 C: 6; 16–82 |
Uric acid Cortisol TAC |
Not specified | NS | — | — | 6/10 |
| Badea et al. 2010 [19] | CC | PD: 85; — C: 49; — |
8-OHdG | Not specified | — | PD 3.00–7.50 C 1.20–1.85 |
Yes | 5/10 |
| Sezer et al. 2012 [14] | CC | PD: 20; 29–58 G: 20; 29–58 C: 20; 29–55 |
8-OHdG | At least 4 sites with PP > 5 mm | S | PD 3.13 ± 0.22 G 1.58 ± 0.13 C 1.56 ± 0.12 |
Yes (Not for PD versus G) |
9/10 |
| Komatsu et al. 2013 [16] | CC | PD: 21; 44.7 ± 8.8 C: 26;41.9 ± 6.2 |
8-OHdG | PDT sensor probe | NS | PD 3.30 ± 1.44 C 2.10 ± 1.41 |
Yes | 7/10 |
| Dede et al. 2013 [7] | CC | PD: 24; 30–55 C: 24; 18–30 |
8-OHdG | At least 2 sites with PP > 5 mm and LB > 30% | NS | PD 0.61 ± 0.14 C 0.50 ± 0.15 |
No | 8/10 |
| Pendyala et al. 2013 [20] | CC | PD: 30; 40–65 C: 30; 40–65 |
TAC | 2 or more sites with PP > 4 mm or LA > 4 mm with bleeding | NS | — | — | 8/10 |
| Miricescu et al. 2014 [8] | CC | PD: 20 C: 20 51.3 ± 7.4 |
8-OHdG MDA TAC GPx |
At least 6 sites with PP > 4 mm, LB > 30% | NS | PD 6.78 ± 1.80 C 6.46 ± 0.93 |
No | 8/10 |
| Hernández-Monjaraz et al. 2014 [21] | CSt | PD: 23 C: 26 |
SOD TBARS TAC |
Not specified | — | — | — | 5/10 |
| Baňasová et al. 2014 [22] | CC | PD: 23; 43 ± 7.6 C: 19; 39.1 ± 8.8 |
TBARS | At least 16 sites with PP > 4 mm in 2 different quadrants | S | — | — | 8/10 |
| Baltacioglu et al. 2014 [23] | CC | PD: 68; 26–42 C: 30; 26–37 |
MDA TOS OSI TAOC |
Multiple sites with PP > 5 mm, LB > 30% and LA > 5 mm. | NS | — | — | 8/10 |
| Trivedi et al. 2014 [24] | CC | PD: 30; 20–65 C: 30; 20–65 |
SOD GR CAT MDA |
At least 2 sites with PP > 4 mm or LA > 4 mm | NS | — | — | 8/10 |
| Almerich-Silla et al. 2015 [6] | CC | PD: 33; 41–45 G:16; 35–43 C:37; 38–43 |
8-OHdG MDA GPx SOD TAOC |
At least 4 sites with PP > 5 mm and LA > 2 mm | NS | PD 5.54 (4.96–6.12); G 2.33 (1.84–2.82); C 2.20 (1.88–2.52) |
Yes (Not for G versus C) |
9/10 |
| Zamora-Perez et al. 2015 [17] | CC | PD: 100; 39.03 C: 60; 40.13 |
8-OHdG | At least 6 sites with PP >6 mm and LA >5 mm | NS | PD 11.13 ± 1.91 C 5.10 ± 1.44 |
— | 9/10 |
N: sample size; CC: case-control; CS: cross-sectional; PD: periodontal disease; G: gingivitis; C: control group; PP: periodontal pocket; LA: loss of attachment; LB: level of bleeding; S: stimulated; NS: not stimulated.