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Potential alterations in human disease
| Disease | Abnormality | References |
| Cystic fibrosis | Decreased accumulation or | [111] |
| depletion | ||
| Acute interstitial | Decreased accumulation or | [112] |
| pneumonias (ARDS) | depletion | |
| Cigarette smoking | Decreased levels in lavage | [113] |
| Bronchopulmonary | Decreased accumulation or | [114,115] |
| dysplasia | depletion | |
| Asthma | Altered activity | [75] |
| Alveolar proteinosis. | Increased accumulation | [116,117] |
| Diabetes mellitus | Decreased activity? | [84] |
