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Increased SP-D accumulation or expression in animal models
| Injury or challenge | Species | Reference |
| Silicosis | Rat | [118] |
| Hyperoxia | Rat | [104] |
| Endotoxin (LPS) | Rat | [103] |
| Challenge with P. aeruginosa | Mouse | [92] |
| Challenge with IAV | Mouse | [62] |
| Challenge with Pneumocystis carinii | SCID mouse | [91] |
| Rat | [119] | |
| Overexpression of interleukin-4 | Mouse | [120] |
SCID, severe combined immunodeficiency.
