Table 1.
Promoters typically chosen for transduction of retinal ganglion cells (RGCs) within the eye.
| Promoter | Specificity for RGCs | Strength of expression in RGCs | Off-target labelling | Size (bp) % of AAV cargo |
References |
|---|---|---|---|---|---|
| CMV | + | +++ | Muller glia Amacrine cells Bipolar cells |
(508–800) (10–17%) |
[10–14] |
|
| |||||
| CAG | + | ++++ | Muller glia Amacrine cells Bipolar cells |
(584–1132) (12–24%) |
[15–17] |
|
| |||||
| SYN1 | +++ | ++ | Amacrine cells | (400–469) (8–10%) |
[20, 21] |
|
| |||||
| Nefh | ++++ | +++ | (2251) (48%) |
[22] | |
|
| |||||
| Thy1 | ++++ | ++ | (6500) (exceeds limit) |
[23] | |
|
| |||||
| Mcp-1 | ++ | +++ | injured cells | 560 (mouse only) (12%) |
[24] |