. 2018 May 2;2018:7071383. doi: 10.1155/2018/7071383

Table 1.

Changes in the frequency of Pfcrt, Pfmdr1, Pfdhfr, and Pfdhps genotypes between the study periods.

Gene	Mutation	Notation	2003–2005	2009–2013	95% CI	P value
Pfcrt	K76T	T	96.1 (223/230)	66.9 (174/260)	22.96–35.44	*P < 0.0001*
Pfcrt	K76T	K	3.9 (7/230)	33.1 (84/260)	22.96–35.44	*P < 0.0001*

Pfmdr1	N86Y	Y	83.6 (189/226)	45.2 (94/208)	30.09–46.71	*P < 0.0001*
	N86Y	N	16.4 (37/226)	54.8 (116/208)	30.09–46.71	*P < 0.0001*
	Y184F	F	97.3 (217/223)	56 (131/234)	30.09–46.71	*P < 0.0001*
	Y184F	Y	2.7 (6/233)	44 (103/234)	30.09–46.71	*P < 0.0001*
	D1246Y	Y	3.1 (7/226)	0 (0/250)	0.84–5.36	*0.02*
	D1246Y	D	96.9 (219/226)	100 (250/250)	0.84–5.36	*0.02*

Pfdhfr	N51I	N	3.6 (08/222)	1.2 (3/243)	−0.41–5.21	0.16
	N51I	I	96.4 (214/222)	98.8 (240/243)	−0.41–5.21	0.16
	C59R	C	2.3 (05/222)	0 (0/243)	0.33–4.27	0.05
	C59R	R	97.7 (217/222)	100 (243/243)	0.33–4.27	0.05
	S108N	S	0.9 (2/222)	0 (0/243)	−0.34–2.14	0.44
	S108N	N	99.1 (220/222)	100 (243/243)	−0.34–2.14	0.44

Pfdhps	A437G	A	13.3 (30/225)	10 (24/240)	−2.54–9.14	0.33
	A437G	G	86.7 (195/225)	90 (216/240)	−2.54–9.14	0.33
	K540E	K	97.8 (220/225)	100 (240/240)	0.28–4.12	P = 0.06
	K540E	E	2.2 (5/225)	0 (0/240)	0.28–4.12	P = 0.06

Letters represent single letter representation of amino acids in the codons of the drug resistance genes. CI = confidence interval. In the above table, mixed infections are considered to have the mutant genotype.