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. 2018 May 7;28(9):1344–1356.e5. doi: 10.1016/j.cub.2018.03.023

Figure 4.

Figure 4

Any Chromosome May Use Either the CENP-E-Dependent or CENP-E-Independent Pathway to Congress, Regardless of Kinetochore Size

(A) Control Indian muntjac fibroblasts stably expressing CENP-A-GFP (green) and treated with 20 nM SiR-tubulin (magenta). Scale bar, 5 μm. Time, hr:min.

(B) Indian muntjac fibroblasts stably expressing CENP-A-GFP (green) and treated with 20 nM SiR-tubulin (magenta) after CENP-E inhibition with 20 nM GSK923295. Scale bars, 5 μm. Time, hr:min. n = 28 cells, pool of six independent experiments.

The arrows indicate the position of large kinetochores from C3X chromosomes. See also Figure S2 and Video S2.