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. Author manuscript; available in PMC: 2018 May 16.
Published in final edited form as: Exp Neurol. 2013 Dec 26;253:146–153. doi: 10.1016/j.expneurol.2013.12.011

Figure 5.

Figure 5

Paclitaxel (10 nM) increases the release of CGRP from sensory neurons in culture in a time-dependent manner. A) Each column represents the mean ± SEM of CGRP released in fmol/well/10 min from wells treated with vehicle or 10 nM paclitaxel for 1, 3, or 5 days as indicated. The first open column of each group represents basal release (B), the shaded column represents release in the presence of 30 nM capsaicin (C), and the second open column of each group represents the recovery of basal release following stimulation (B). An asterisk indicates a significant difference in capsaicin-evoked release compared to release from the vehicle-treated neurons (p<0.05, N=10–12) using a two-way ANOVA with Bonferroni’s post-hoc test. B) Each column is the mean ± SEM of total CGRP content in fmol/well (N=10–12) from cultures treated with vehicle (Veh) or paclitaxel (Pac) for the duration of time as indicated.