Table 2. Upregulated genes of selected enriched gene ontology categories following irradiation are shown based on sets of statistically significant changes (P < 0.05).

Gene Ontology Category	P-value	Fold change	Gene symbol	Gene description
GO:0010718:Positive regulation of epithelial to mesenchymal transition	4.90E–03	2.32	BAMBI	BMP and activin membrane bound inhibitor
		2	GLIPR2	GLI pathogenesis related 2
		2.23	AXIN2	axin 2
		4.78	COL1A1	collagen type I alpha 1 chain
		2.79	TGFB3	transforming growth factor beta 3
GO:0001525: Angiogenesis	2.00E–02	2.46	CXCL8	C-X-C motif chemokine ligand 8
		5.1	EPHB3	EPH receptor B3
		2.2	EPHB4	EPH receptor B4
		5.79	ACKR3	atypical chemokine receptor 3
		2	CSPG4	chondroitin sulfate proteoglycan 4
		2.48	COL8A1	collagen type VIII alpha 1 chain
		3	NRXN3	neurexin 3
		3.16	NDNF	neuron derived neurotrophic factor
		3.68	NRP2	neuropilin 2
		2.611	SERPINE1	serpin family E member 1
		3.2	ZC3H12A	zinc finger CCCH-type containing 12A
GO:0016049: Cell growth	3.00E–02	14.44	ROS1	ROS proto-oncogene 1, receptor tyrosine kinase
		3.07	EDN1	endothelin 1
		2.43	IL7R	interleukin 7 receptor
		3.16	NDNF	neuron derived neurotrophic factor
		2.79	TGFB3	transforming growth factor beta 3
GO:0008283: Cell proliferation	2.30E–02	2.18	E2F8	E2F transcription factor 8
		4.84	ERG	ERG, ETS transcription factor
		14.44	ROS1	ROS proto-oncogene 1, receptor tyrosine kinase
		4.47	ALK	anaplastic lymphoma receptor tyrosine kinase
		2.23	AXIN2	axin 2
		3	CDC25A	cell division cycle 25A
		2.02	CSPG4	chondroitin sulfate proteoglycan 4
		4.19	CYP1A1	cytochrome P450 family 1 subfamily A member 1
		3.23	DLX5	distal-less homeobox 5
		2.14	FSCN1	fascin actin-bundling protein 1
		2.76	FGF5	fibroblast growth factor 5
		2.62	GRPR	gastrin releasing peptide receptor
		5.56	MYH10	myosin heavy chain 10
		2.47	PDK1	pyruvate dehydrogenase kinase 1
		2.25	UHRF1	ubiquitin like with PHD and ring finger domains 1
GO:0004222: Metalloendopeptidase activity	5.70E–04	3	ADAM12	ADAM metallopeptidase domain 12
		2.79	ADAM19	ADAM metallopeptidase domain 19
		2.59	ADAMTS1	ADAM metallopeptidase with thrombospondin type 1 motif 1
		2.73	ADAMTS14	ADAM metallopeptidase with thrombospondin type 1 motif 14
		2.25	BMP1	bone morphogenetic protein 1
		3.15	MMP12	matrix metallopeptidase 12
		5.55	MMP3	matrix metallopeptidase 3
		5.69	MMP7	matrix metallopeptidase 7
		2.35	MME	membrane metalloendopeptidase
		2.4	TSHZ2	teashirt zinc finger homeobox 2
GO:0001666: Response to hypoxia	2.90E–02	5.69	ABAT	4-aminobutyrate aminotransferase
		2.73	BNIP3	BCL2 interacting protein 3
		5.6	CA9	carbonic anhydrase 9
		4.17	CYP1A1	cytochrome P450 family 1 subfamily A member 1
		3.84	EGLN3	egl-9 family hypoxia inducible factor 3
		2.25	LOXL2	lysyl oxidase like 2
		2.72	MUC1	mucin 1, cell surface associated
		10.81	POSTN	periostin
		2.79	TGFB3	transforming growth factor beta 3
		1.80	HIF-1α	Hypoxia-inducible factor 1-alpha
GO:0016477: Cell migration	2.90E–04	2.32	BAMBI	BMP and activin membrane bound inhibitor
		2.39	EPHA3	EPH receptor A3
		5.1	EPHB3	EPH receptor B3
		4.84	ERG	ERG, ETS transcription factor
		2.95	WWC1	WW and C2 domain containing 1
		2.06	BDKRB1	bradykinin receptor B1
		2	CSPG4	chondroitin sulfate proteoglycan 4
		2.41	COL5A1	collagen type V alpha 1 chain
		2.14	FSCN1	fascin actin-bundling protein 1
		3.66	LCP1	lymphocyte cytosolic protein 1
		3.3	PODXL	podocalyxin like
		4.48	PSG2	pregnancy specific beta-1-glycoprotein 2
		2.83	SDC1	syndecan 1

Experiments were performed in triplicates.