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. 2018 May 4;9(34):23661–23669. doi: 10.18632/oncotarget.25320

Table 2. Associations between family history of prostate cancer (PCa) and prostate cancer risk.

Cases
n = 819 (48.2%)
Controls
n = 879 (51.8%)
OR1 95% CI2
Family history of PCa in first degree relatives
No 549 (75.2) 723 (90.4) 1.00 reference
Yes 181 (24.8) 77 (9.6) 3.10 (2.32–4.15)
 Cancer >60 years 126 (17.4) 64 (8.0) 2.57 (1.86–3.54)
 Cancer <60 years 49 (6.8) 13 (1.6) 5.15 (2.75–9.62)
Number of family history of PCa in first degree relatives
None 549 (75.2) 723 (90.4) 1.00 reference
1 159 (21.8) 70 (8.8) 2.98 (2.20–4.03)
≥2 22 (3.0) 7 (0.9) 4.44 (1.87–10.6)
p trend < 0.001
Family history of PCa in fathers
No 549 (75.2) 723 (90.4) 1.00 reference
Yes 127 (18.8) 57 (7.3) 2.85 (2.04–3.98)
 Cancer >60 years 104 (15.5) 51 (6.5) 2.60 (1.82–3.71)
 Cancer <60 years 19 (2.8) 6 (0.8) 4.04 (1.60–10.2)
Family history of PCa in brothers
No 549 (75.2) 723 (90.4) 1.00 reference
Yes 65 (46.7) 27 (45.8) 3.79 (2.36–6.10)
 Cancer >60 years 33 (16.5) 18 (17.7) 2.73 (1.51–4.91)
 Cancer <60 years 30 (16.5) 9 (17.7) 5.91 (2.66–13.1)

1OR: Odds Ratios adjusted for age, ethnic origin and number of male relatives.

295% CI: 95% Confidence Interval.