Table 5. Associations between family history of breast cancer and prostate cancer risk according to Gleason score.
| Low or intermediate grade prostate cancer Gleason score ≤ 7 (3 + 4) | High grade prostate cancer Gleason score ≥ 7 (4 + 3) | ||||
|---|---|---|---|---|---|
|
Controls n = 879 (%) |
Cases n = 623 (%) |
OR1 95% CI2 |
Cases n = 183 (%) |
OR1 95% CI2 | |
| Family history of BCa in first degree relatives | |||||
| No | 711 (85.4) | 498 (85.6) | 1.00 reference | 138 (80.2) | 1.00 reference |
| Yes | 122 (14.6) | 84 (14.4) | 1.04 (0.76–1.41) | 34 (19.8) | 1.42 (0.92–2.19) |
| Cancer >50 years | 80 (9.1) | 48 (7.7) | 0.86 (0.57–1.29) | 14 (7.7) | 0.96 (0.52–1.77) |
| Cancer <50 years | 32 (3.6) | 32 (3.6) | 1.66 (0.97–2.85) | 13 (7.1) | 2.42 (1.19–4.90) |
| Number of family history of BCa in first degree relatives | |||||
| None | 711 (85.4) | 498 (85.6) | 1.00 reference | 138 (80.2) | 1.00 reference |
| 1 | 110 (13.2) | 76 (13.1) | 1.02 (0.74–1.40) | 32 (18.6) | 1.47 (0.94–2.30) |
| ≥2 | 12 (1.4) | 8 (1.4) | 1.23 (0.49–3.07) | 2 (1.2) | 0.90 (0.20–4.14) |
| p trend = 0.74 | p trend = 0.18 | ||||
| Family history of BCa in mothers | |||||
| No | 711 (85.4) | 498 (85.6) | 1.00 reference | 138 (80.2) | 1.00 reference |
| Yes | 69 (8.8) | 45 (8.3) | 0.95 (0.64–1.42) | 16 (10.4) | 1.21 (0.68–2.17) |
| Cancer >50 years | 53 (6.8) | 31 (5.0) | 0.91 (0.56–1.48) | 10 (5.5) | 1.11 (0.54–2.26) |
| Cancer <50 years | 15 (1.9) | 14 (2.3) | 1.22 (0.55–2.71) | 6 (3.3) | 2.24 (0.81–6.20) |
| Family history of BCa in sisters | |||||
| No | 711 (85.4) | 498 (85.6) | 1.00 reference | 138 (80.2) | 1.00 reference |
| Yes | 60 (7.8) | 39 (7.3) | 1.03 (0.67–1.58) | 16 (10.4) | 1.39 (0.76–2.54) |
| Cancer >50 years | 32 (3.6) | 21 (3.4) | 0.87 (0.47–1.61) | 5 (2.7) | 0.82 (0.30–2.21) |
| Cancer <50 years | 16 (1.8) | 13 (2.1) | 1.50 (0.69–3.26) | 3 (1.6) | 1.11 (0.31–4.02) |
| Family history of BCa in daughters | |||||
| No | 711 (85.4) | 498 (85.6) | 1.00 reference | 138 (80.2) | 1.00 reference |
| Yes | 2 (0.3) | 7 (1.4) | 5.64 (1.16–27.5) | 4 (2.8) | 9.25 (1.66–51.6) |
1OR: Odds Ratios adjusted for age, ethnic origin, number of first-degree female relatives and famili history of prostate cancer in first-degree relatives.
295% CI: 95% Confidence Interval.