Table 2A. Univariate analysis of risk factors for acute and late skin toxicity.
| Acute skin toxicity* | Late skin toxicity* | |||||
|---|---|---|---|---|---|---|
| No (%) | Yes (%) | P-value | No (%) | Yes (%) | P-value | |
| Age | ||||||
| Median | 51 | 55 | 0.1987 | 51 | 56 | 0.039 |
| [min; max] | [25; 74] | [32; 76] | [25; 74] | [32; 76] | ||
| BMI | ||||||
| Median | 23.5 | 27.3 | < 0.0001 | 24.02 | 27.3 | 0.004 |
| [min; max] | [16.3; 53.4] | [17.7; 44.5] | [16.3; 53.4] | [18.9; 51.3] | ||
| Tabaco use | ||||||
| Yes | 13 (11.8) | 17 (20.2) | 0.159 | 20 (15.5) | 7 (13.0) | 0.819 |
| No | 94 (85.5) | 65 (77.4) | 106 (82.2) | 45 (83.3) | ||
| Unknown | 3 (2.7) | 2 (2.4) | 3 (2.3) | 2 (3.7) | ||
| Breast cup size | ||||||
| A-B-C | 72 (65.5) | 49 (58.3) | 0.1134 | 89 (69.0) | 28 (51.9) | 0.018 |
| D-E-F-G | 20 (18.2) | 25 (29.8) | 24 (18.6) | 19 (35.2) | ||
| Unknown | 18 (16.4) | 10 (11.9) | 16 (12.4) | 7 (13.0) | ||
| History of CV disease | ||||||
| Yes | 26 (23.6) | 32 (38.1) | 0.0397 | 38 (29.5) | 18 (33.3) | 0.725 |
| No | 83 (75.5) | 52 (61.9) | 90 (69.8) | 36 (66.7) | ||
| Unknown | 1 (0.9) | 0 (0.0) | 1 (0.8) | 0 (0.0) | ||
| AHT | ||||||
| Yes | 10 (9.1) | 21 (25.0) | 0.005 | 19 (14.7) | 11 (20.4) | 0.385 |
| No | 99 (90.0) | 63 (75.0) | 109 (84.5) | 43 (79.6) | ||
| Unknown | 1 (0.9) | 0 (0.0) | 1 (0.8) | 0 (0.0) | ||
| Diabetes | ||||||
| Yes | 4 (3.6) | 5 (6.0) | 0.5062 | 8 (6.2) | 0 (0.0) | 0.107 |
| No | 105 (95.5) | 79 (94.0) | 120 (93.0) | 54 (100.0) | ||
| Unknown | 1 (0.9) | 0 (0.0) | 1 (0.8) | 0 (0.0) | ||
| Dyslipidaemia | ||||||
| Yes | 13 (11.8) | 15 (17.9) | 0.3036 | 18 (14.0) | 10 (18.5) | 0.514 |
| No | 96 (87.3) | 69 (82.1) | 110 (85.3) | 44 (81.5) | ||
| Unknown | 1 (0.9) | 0 (0.0) | 1 (0.8) | 0 (0.0) | ||
*For acute skin toxicity: “No” included grade 0 and 1; for late skin toxicity: “No” included only grade 0.
Abbreviations: BMI = Body mass index; AHT = arterial hypertension; CV = cardiovascular.