Table 1. Summary of immunohistochemical analyses of fibrosis in lung metastases from mouse models of breast cancera.
| Model: | ER/PR: | HER2: | Metastatic Efficiency: |
Modified Ashcroft Scoreb: |
α-SMAc: | Collagen Ic: | |
|---|---|---|---|---|---|---|---|
| Metastasis: | Lung: | ||||||
| R3T | –/– | Nl | 60 | 0 | 1 | + | – |
| 4T1 | –/– | Nl | 100 | 1 | 3 | +++ | + |
| TS/A-E1 | +/– | Nl | 100 | 2 | 2 | ++ | – |
| E0771 | –/– | Nl | 50 | 1 | 4 | +/– | + |
| 6DT1 | –/– | Nl | 90 | 1 | 2 | ++ | ++ |
| Mvt1 | –/– | Nl | 90 | 1 | 3 | ++ | +++ |
| HRM1 | +/– | Nl | 80 | 1 | 5 | ++++ | ++ |
| M6 | –/– | Nl | 55 | 3 | 5 | ++++ | ++++ |
| F3II | –/– | Nl | 70 | 1 | 5 | ++ | + |
| EMT6 | +/– | Nl | 100 | 1 | 5 | +++++ | –/+ |
aMultiple sections of lung metastases were stained for trichrome, α-SMA and collagen I. Model system molecular subtype by immunohistochemistry and metastatic efficiency were previously reported (30).
bSee Supplementary Table 1. Ranges from 0–8.
cGraded on a – to +++++ scale in intensity.