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Xenograft study was performed as in Figure 4 with GBMX16 iSTAT3-KD GICs rescued with Y705F-STAT3 or S727A-STAT3. (A) Representative bioluminescent images of mice at 21 days post-injection. (B) Quantification of the bioluminescence signal detected at 1, 2 and 3 weeks post-injection. (C) Photographs of the tumors extracted from the mice at necropsy. (D) H&E and Ki67 staining of tumor tissue at necropsy.
