Table 1. The effects of STAT3-KD and rescue with WT-STAT3 on gene expression in GBMX16 GICs.

Neuro Panel
Gene	Alias	STAT3 KDa	Rescueb	Function
		Fold Change
AMIGO	ALI2, AMIGO-1	1.58 ⇓	1.16 ⇑	Myelination
ARRB2	ARB2, ARR2	1.31 ⇓	1.33 ⇑	Neural Structure, Signaling
ANG	ALS9, RNASE4	3.51 ⇓	1.28 ⇑	Angiogenesis
DRD2	D2DR, D2R	2.42 ⇓	6.67 ⇑	Transmitter release
GATA2	DCML, IMD21	58.06 ⇓	46.9 ⇑	Angiogenesis, Chromatin Modification
CDS1	CDS	12.34 ⇑	3.3 ⇓	Metabolism, Signaling
CHD4	Mi-2b, Mi2-beta	1.51 ⇑	3.1 ⇓	Chromatin Modification

Immune Panel
Gene	Alias	STAT3 KD	Rescue	Function
		Fold Change
PBK	SPK, CT84	3.54 ⇓	2.06 ⇑	Tumorigenesis
S100B	NEF	1.36 ⇓	1.9 ⇑	Cell Cycle
THY1	CD90	3.5 ⇓	2 ⇑	Adhesion
HMGB1	SBP-1	2.15 ⇓	1.68 ⇑	Metastasis
CDK1	CDC2	2.51 ⇓	1.07 ⇑	Cell Cycle
HLADPB1	DPB1	1.25 ⇓	4.4 ⇑	Immunity
CD200	OX-2, MOX1	7.2 ⇓	3.74 ⇑	Immune suppression
CCL2	MCAF, MCP1	13.7 ⇓	6.25 ⇑	Inflammation and Immune regulation

Cancer Panel
Gene	Alias	STAT3 KD	Rescue	Function
		Fold Change
BTG1	APRO2	2.92 ⇑	5.91 ⇓	Anti-tumorigenic
COL6A1	OPLL, BTHLM1	6.54 ⇑	4.5 ⇓	Adhesion
PMP22	CIDP, CMT1A	1.82 ⇑	2.7 ⇓	Anti-proliferative
HIF1A	HIF1-alpha	1.46 ⇑	2.63 ⇓	Metabolism, Apoptosis, Angiogenesis

^a Fold change = gene expression in control GBMX16/STAT3-KD.

^b Fold change = gene expression in WT-STAT3 rescue/STAT3-KD.