Table 3. Univariable and multivariable Cox regression analysis.
| Univariable | Multivariable | |||||
|---|---|---|---|---|---|---|
| HR | p-value | 95% CI | HR | p-value | 95% CI | |
| Freedom from recurrence | ||||||
| Histology (TC vs. Thymoma) | 4.93 | 0.002 | 1.76–13.7 | 8.55 | 0.036 | 1.14–62.5 |
| Tumor Stage (I–II vs. III–IV) | 2.60 | 0.066 | 0.94–7.14 | 0.68 | 0.673 | 0.12–4.02 |
| Fibrinogen (high vs. low) | 2.86 | 0.053 | 0.99–8.26 | 1.40 | 0.601 | 0.40–4.95 |
| NLR (high vs. low) | 3.95 | 0.014 | 1.32–11.7 | 3.14 | 0.145 | 0.67–14.7 |
| PLR (high vs. low) | 2.00 | 0.259 | 0.60–6.67 | 0.44 | 0.350 | 0.08–2.46 |
| Cause specific survival | ||||||
| Histology (TC vs. Thymoma) | 23.3 | 0.004 | 2.68–200.0 | 3.56 | 0.442 | 0.14–90.9 |
| Tumor Stage (I-II vs. III-IV) | 12.35 | 0.022 | 1.43–111.1 | 3.10 | 0.459 | 0.16–62.5 |
| Fibrinogen (high vs. low) | 17.24 | 0.012 | 1.87–166.7 | 9.09 | 0.149 | 0.45–166.7 |
| NLR (high vs. low) | 62.5 | 0.265 | 0.04–100.0 | 0.61 | 0.677 | 0.06–6.10 |
| PLR (high vs. low) | 2.83 | 0.257 | 0.47–16.5 | 1.07 | 0.963 | 1.00–1.60 |
Presented data indicate the prognostic impact of tested factors. Patients were dichotomized into high and low subgroups using cut-off values of 452.5 mg/dL for Fibrinogen, 4.0 for NLR, and 136.5 for PLR. TC, Thymic carcinoma; HR, Hazard Ratio; CI, Confidence Interval; NLR, Neutrophil-to-Lymphocyte Ratio; PLR, Platelet-to-Lymphocyte Ratio.