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. Author manuscript; available in PMC: 2018 May 16.
Published in final edited form as: Nature. 2014 Dec 24;519(7542):223–228. doi: 10.1038/nature14135

Figure 2. Gene-specific significance of enrichment for DNMs.

Figure 2

The –log10(p) value of testing for mutation enrichment is plotted only for each gene with at least one mutation in DDD children. On the X-axis is the p value of the most significant test in the DDD dataset, and on the Y-axis is the minimal p value from the significance testing in the meta-analysis dataset. Red indicates genes already known to be associated with DDs (in DDG2P). Only genes with a p value of less than 0.05/18,272 (red lines) are labeled.