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. 2018 May 10;13:2803–2819. doi: 10.2147/IJN.S156434

Figure 6.

Figure 6

Cell toxicity, and ablation in vitro following incubation with GP-PGA-Fe3O4-CDs@BPQDs.

Notes: (A) Serum biochemistry data for C57BL/6 mice injected with PBS (5 and 30 days postinjection) and GP-PGA-Fe3O4-CDs@BPQDs (5 and 30 days postinjection). (B) ROS generation detected by mean fluorescence for GP-PGA-Fe3O4-CD@BPQD-internalized HeLa cells followed by irradiation with and without NaN3 preprocessing. (C) Tail-DNA and tail-moment analysis. (D) Fluorescence images of calcein AM/PI-stained HeLa cells under various conditions: laser only (a, 0.5 W/cm2), laser only (b, 2 W/cm2), 50 μg/mL GP-PGA-Fe3O4-CDs@BPQDs + laser (c, 660 nm, 0.5 W/cm2, PDT), 50 μg/mL GP-PGA-Fe3O4-CDs@BPQDs + laser (d, 808 nm, 2 W/cm2, PTT), and 50 μg/mL GP-PGA-Fe3O4-CDs@BPQDs + laser (e, 660 + 808 nm, PDT/PTT). Scale bar =100 μm. (E) Relative viability of HeLa cells under various conditions: laser only (a, 0.5 W/cm2), laser only (b, 2 W/cm2), 50 μg/mL GP-PGA-Fe3O4-CDs@BPQDs + laser (c, 660 nm, 0.5 W/cm2, PDT), 50 μg/mL GP-PGA-Fe3O4-CDs@BPQDs + laser (d, 808 nm, 2 W/cm2, PTT), and 50 μg/mL GP-PGA-Fe3O4-CDs@BPQDs + laser (e, 660 + 808 nm, PDT/PTT).

Abbreviations: GP, genipin; PGA, polyglutamic acid; CDs, carbon dots; BPQDs, black phosphorus quantum dots; ROS, reactive oxygen species; AM, acetoxymethyl; PI, propidium iodide; PDT, photodynamic therapy; PTT, photothermal therapy; Cr, creatinine; ALT, alanine aminotransferase; TB, total bilirubin; AST, aspartate aminotransferase; con, concentration.