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. 2018 May 1;9(33):23126–23148. doi: 10.18632/oncotarget.25226

Figure 3. IL-34 expression and overall survival across molecular subtypes of breast cancer.

Figure 3

(A) Kaplan–Meier plots of overall survival in IL-34-high and IL-34-low expressing TCGA BRCA patients (n = 1056). Median IL-34 expression was used as cut-off for group separation. Log rank tests were calculated. (B) IL-34 mRNA expression in normal breast tissue and in PAM50 breast cancer subclasses. The bar graph shows the IL-34 mRNA levels (log2) across normal breast tissue (n = 113) and the molecular subtypes of breast cancer (luminal A, n = 412; luminal B, n = 188; HER2-enriched, n = 64; basal, n = 140) of the TCGA BRCA dataset. Kruskal–Wallis and Dunn’s multiple comparison tests were calculated. Error bars indicate standard deviations. *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001. (C) Kaplan–Meier plots of overall survival in IL-34-high and IL-34-low expressing TCGA BRCA patients stratified by PAM50 subclasses (luminal A, n = 412; luminal B, n = 188; HER2-enriched, n = 64; basal, n = 140). Median IL-34 expression was used as cut-off for group separation. Log rank tests were calculated.