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. 2018 May 1;9(33):23126–23148. doi: 10.18632/oncotarget.25226

Figure 5. Prognostic significance and tumor-specific changes of expression for the IL-34 system in breast cancer patients.

Figure 5

(A) IL-34, CSF-1, CSF-1R, PTPRZ1, and syndecan-1 expression in TCGA breast cancer samples (n = 1102) vs. normal breast tissue (n = 113). Scatter plots show relative mRNA expression (log2). Each dot represents a single tissue sample. Black lines indicate means and standard deviations. P-values were determined via Mann–Whitney U tests (two-sided). (B) CSF-1, CSF-1R, PTPRZ1, and syndecan-1 mRNA expression in normal breast tissue and in PAM50 breast cancer subclasses. The bar graph shows the mRNA levels (log2) across normal breast tissue (n = 113) and the molecular subtypes of breast cancer (luminal A, n = 412; luminal B, n = 188; HER2-enriched, n = 64; basal, n = 140) of the TCGA BRCA dataset. Kruskal–Wallis and Dunn’s multiple comparison tests were calculated. Error bars indicate standard deviations. *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001. (C) Kaplan–Meier plots of overall survival between CSF-1, CSF-1R, PTPRZ1, and SDC1 high and low expressing breast cancer patients (n = 1056) of the TCGA BRCA dataset. Median expression values were used as cut-offs for group separation. Log rank tests were calculated.