Table 6. Macrophage infiltration and stromal cell/immune cell infiltration in breast tumors stratified by PAM50 calls.

Luminal A subtype - Categorized Pearson’s product-moment correlation
	M0	M1	M2	Stromal sc	Immune sc	ESTIMATE sc
	r	r	r	r	r	r
IL-34	−	++	---	++	++	+++
CSF-1			+	++	++	++
CSF-1R		+		+++	+++	+++
PTPRZ1	−	+	--	+		+
SDC1	+			+++		++

Luminal B subtype - Categorized Pearson’s product-moment correlation
	M0	M1	M2	Stromal sc	Immune sc	ESTIMATE sc
	r	r	r	r	r	r
IL-34		++	--	++	++	++
CSF-1			+	++	+++	+++
CSF-1R		+		+++	+++	+++
PTPRZ1
SDC1		+		++	+	++

HER2 subtype -Categorized Pearson’s product-moment correlation
	M0	M1	M2	Stromal sc	Immune sc	ESTIMATE sc
	r	r	r	r	r	r
IL-34			--		++	++
CSF-1				+++	+++	+++
CSF-1R				+++	+++	+++
PTPRZ1
SDC1	++	−	++	++

Basal subtype -Categorized Pearson’s product-moment correlation
	M0	M1	M2	Stromal sc	Immune sc	ESTIMATE sc
	r	r	r	r	r	r
IL-34				+	+	+
CSF-1		++	−	+++	+++	+++
CSF-1R		++		+++	+++	+++
PTPRZ1	+	−			−
SDC1

Association between mRNA expression of 5 genes and macrophage infiltration as well as stromal cell/immune cell infiltration in breast tumors stratified by PAM50 calls from the TCGA BRCA dataset.

M0, M0 macrophages; M1, M1 macrophages; M2, M2 macrophages; Stromal sc, Stromal score; Immune sc, Immune score; Estimate sc, Estimate score. r, categorized Pearson’s correlation coefficient;

(---), −1.0 to −0.5, strong negative association; (--), −0.5 to −0.3, weak negative association; (−), −0.3 to 0.1, little association.

(+), +0.1 to 0.3, little association; (++) +0.3 to +0.5, weak positive association; (+++), +0.5 to +1.0, strong positive association.

M0, M1, M2 (TCIA database); Stromal sc., Immune sc., Estimate sc. (ESTIMATE database).