Skip to main content
. 2018 May 1;9(33):23289–23305. doi: 10.18632/oncotarget.25289

Figure 7. Anti-STn ADCs impede OvCa xenograft growth in vivo and target STn+ cells.

Figure 7

(A) Mice bearing tumors derived from OVCAR3 were treated with vehicle, unconjugated S3F, S3F-CL-MMAE, unconjugated 2G12-2B2, or 2G12-2B2-CL-MMAE. Tumors were measured twice weekly, and the percentage change in tumor volume compared to the baseline volume (100%) is shown. Error bars represent the mean ± SEM *p < 0.05. (B) Xenografts collected at the end of the in vivo treatment were examined to assess the relative frequency of STn-/CD133-, STn+/CD133-, STn-/CD133+ and STn+/CD133+ sub-populations.