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. 2018 May 1;9(33):22929–22944. doi: 10.18632/oncotarget.25149

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Copyright: © 2018 Ogura et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) The effect byFIRs, FIR andΔexon2 siRNA to FBW7, cyclin E, c-Myc, Notch1, TP53, GSK3-β and P27(Kip1) were examined in TE2 cells (benign TP53). (B) Total FIR and FIR siRNA increased cyclin E in ESCC cells (TE2 cells) in a dose dependent manner. FIRΔexon2 siRNA suppressed cyclin E expression in ESCC cells.