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(A) Esophageal cancer cell lines (TE2) were exposed to CDDP. The expression of TP53, and FIR was decreased, whereas that of Notch1 was increased. (B) Cyclin E was increased by CDDP treatment (arrows). (C) γH2AX was an indicator of DNA damage as well as T.Tn cells that has pathogenic TP53 mutation (arrows). (D) 5FUtreatment increased cyclin E expression in esophageal cancer cells (TE1 and TE2 cells).
