Table 2.

The Main Pharameters after Oral Administration of Ost-suspension and Ost-S100-NPs in rats. Mean ± SE (n = 8).

Parameters	Units	Ost-suspension	Ost-S100-NP
Cmax	μg·ml−1	1.87 ± 0.24	3.15 ± 0.29**
Tpeak	h	2.25 ± 0.21	4.21 ± 0.25**
ka	h−1	1.25 ± 0.16	0.44 ± 0.09**
k10	h−1	0.43 ± 0.02	0.45 ± 0.02*
AUC	μg·h·ml−1	55.47 ± 3.33	93.58 ± 4.85**
CL	mg·kg−1·h−1/ μg·ml−1	0.45 ± 0.02	0.27 ± 0.01**
MRT	h	22.10 ± 0.87	23.48 ± 0.64**
Fr(%)		—	168.7%

Notes.

^*P < 0.05 vs. Ost-suspension;

^**P < 0.01 vs. Ost-suspension.

C_max: maximum concentration; T_peak: time to reach C_max; k_a: the absorption constant from gastrointestinal tract to central compartment; k₁₀: elimination constant of the central compartment; AUC:area under concentration curve; CL: clearance; MRT: mean retention time; Relative bioavailability: Fr % = ( AUC_Ost-S100-NP / AUC_{Ost-suspension}) × 100%