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. 2018 Mar 19;9(1):683–699. doi: 10.1080/21505594.2018.1438025

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Induction of Enterococcus-activated genes through known C. elegans immune pathways and by heat-killed bacteria. (A) Heat-map of Enterococcus-activated genes in wild-type N2 worms or immune pathway mutant worms (pmk-1(km25), bar-1(ga80), pmk-1(km25);bar-1(ga80), and fshr-1(ok778)), during infection with E. faecalis (top panel) or E. faecium (bottom panel). The heat-map reflects data from 2–3 biological replicates for each mutant analyzed. (b) Heat-map of Enterococcus-activated genes in wild-type N2 or immune pathway mutant worms, after 8 hours of exposure to heat-killed E. faecalis (top panel) or heat-killed E. faecium (bottom panel). For comparison, induction in N2 wild-type worms by live E. faecalis or E. faecium is shown in the bottom row of each panel. The heat-map reflects data from 2–3 biological replicates for each mutant analyzed. Genes are ordered by their degree of induction on E. faecalis in N2 worms, from red (most highly upregulated) to blue (most highly downregulated).