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. 2018 May 15;9(1):923–929. doi: 10.1080/21505594.2018.1460064

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Spleen histopathology at different magnifications in transgenic mice either: (A) non-infected (negative control), (B) infected by the wild-type capsulated carriage isolate (CarB-3141-OFF) unable to express HmbR or (C) infected by the phase variant capsulated carriage isolate (CarB-3141-ON) able to express HmbR. Bacteria (arrow) and macrophages (arrow heads) are visible only for this later isolate. Presented data are typical representative pictures of three repeats for each of the two isogenic isolates (CarB-3141-OFF and CarB-3141-ON).